Your raise is only getting called by a hand that has you crushed.
You're not really even priced in to set mine at this point. If you have no other reads, this is a fold.

By the way, just for clarity: Is it 22 hands for the VPIP/PFR or for the 3-bet? CPFR and 3-bet don't accumulate every hand, and are probably not even beginning to converge until 50+ opportunities for most players (the smaller the % the more hands it takes to converge). At the tables I play, that would be 150+ hands total on the person before I cared too much what the 3-bet % was. Until then (or they show me otherwise), I put them on a nits range.