setmine w/ 22-88 in blinds cant be a losing play long run w/ 100bb effective stack when we call 3-4bb pre, our implied odds are somewhere around 25-30:1.... at micros setmining is always +EV, higher stakes they will drop in profitability especially OOP, cause villains dont stack of so easily w/ TPTK,2pair, FD etc...but at 4nl i cant say calling 22-88 in blinds is -EV