I believe that destacking isn't the MAIN goal, because I like to make +EV plays that I know are gonna help me in the long run, but I don't shy away from de-stacking people.

However I try to think of a person's stack as irrelevant in NLHE because I pretend that every person has an infinite amount of chips and that I cant ever take all their money, but I have to try and take the biggest amount possible from them that I think they are going to give up when I have them beat in a hand. Alot of the times this means "de-stacking" them from what they have brought to the table.