I play full-ring and raise all of these from LP no matter how many limpers and probable cold-callers there are. They're all always raise, except A5s and 22 are only sometimes, depending on opponents and my image. There are a lot of nits where I play, so a pre-flop raise + c-bet in position = $.

If you're in a game where a 4xbb+1bb/limper raise from LP still gets 4 callers, 1) congratulations and 2) you should probably limp behind with 22/77/A5s.