i love playing with a big stack. i find i tend to play my best when i have a big stack. I do play a little looser, but its probably on the scale of 5% more hand or so, which really isn't too much. I find having the big stack i am able to press my edges more effectively, i am smarter about drawing, and in general people call me more. only problem i've ever had with it, is on royalvegas i like using the little slider to raise, and the one or two times i've gotten to 4-5x the buy-in, the slider increments get a little too big. Oh woe is me.