I've attempted 50NL seriously once, and failed miserably by loosing 5 buy-ins in one session. My biggest losses were hands where I'd c-bet the flop and turn with ace high, as well as paying off the straights and flushes that people were chasing. I can't understand it just yet... I bet the pot ($5), they call(33%) with their flush draw(35%). Pot ends up being $40 in the end somehow.... ??

I found that the tables are only a little tighter @ 50NL, but the biggest difference is player quality post flop.