If they're not calling down in these spots, then bluff them more often. Then run your bluff line for value and make figuring out if you have a hand or not their problem.

When I have a lock like this, sometimes I run passive line (particularly against an opponent who is betting big, often and light.) But my default is to just blast away and sometimes it's pretty amusing to see what called down or played back at me.

Then again, I'm a pretty big spewtard and ruthless when I find someone who will let me pick on them.