Thanks a million for the advice Griffey. I'm on it like a car bonnet.

I've got a question though. Assuming 100bb stacks so there isn't ridiculous depth to the strategy. On the turn in your example villain bets pot and we have to defend 32 combos, we can defend by calling or raising. So if we have a raise/fold range does that count as defending? Probably a stupid question.

Another thing, since there is another betting street to come do we need to be defending 50% to potsized bets, or does this not matter since we're looking at GTO strategies vs an unkown? Like obviously if we had a read that villain bets a weak range when he bets pot we can increase our EV by continuing less than 50% with a stronger range.

I think I'm overcomplicating things, since you're only going to be playing as close to GTO as possible vs unknowns, and then once you spot a leak you can deviate to exploit it.

Sorry for my disorganized rant!