Yeah it makes sense that VPIP would eventually open up a bit for me. I gave it some though and here are some of the reasons why I think bjaust suggested that I will open my game up over time:

a) after getting more experience at 6max I will be able to identify thinner value preflop that I otherwise overlooked, thus will slowly begin picking up more spots to open/isolate that I never saw before.
b) I will begin to develop a better sense of when to 3bet light/squeeze, which is something that hasn't quite developed yet for my game since I'm still grinding micro's, thus the games are softer so there's not usually a need to be 3betting light unless coming across another TAG who is stealing alot.
c) getting better postflop will naturally give me more opportunity to play wider ranges preflop, because of the ability to outmaneuver opponents.

I've began isolating much wider vs a few opponents in my last couple sessions who I had reads on postflop. One player would c/f almost any missed flop, while another would always donk the turn when I checked the flop, so I could check back alot of missed hands on the flop and raise turns where I felt he wasn't representing anything on the board that fits in his range.

I suppose it's really a matter of really paying alot of attention to your opponents and finding 'non-standard' plays that exploit their tendencies to gain more EV.

I've also discovered that in 6max you can use your image to your advantage more, even at the micro's. For example after showing down a strong hand after making a preflop raise you can really run the table over until they adjust (adjust = get sick of you raising alot and then make spew plays back at you).