Gonna try and post some examples in my next few posts of how I try to exploit reg's while on the button. An important thing that I've tried to keep an eye on while multi-tabling are the villains who will limp a small-medium pair in any position and play solely for set value. Their play is extremely exploitable via isolation, and it only takes a few hands of observation to realize what they're doing:

Villain is 17/5 over a 1000 hands, has never limped a big hand from EP that I've noticed

PokerStars No-Limit Hold'em, $0.25 BB (9 handed) - Poker-Stars Converter Tool from FlopTurnRiver.com

MP1 ($25.35)
MP2 ($33.45)
MP3 ($25)
CO ($25)
Hero (Button) ($25)
SB ($25)
BB ($29.35)
UTG ($42.45)
UTG+1 ($27.35)

Preflop: Hero is Button with ,
1 fold, UTG+1 calls $0.25, 4 folds, Hero bets $1.25, 2 folds, UTG+1 calls $1

Flop: ($2.85) , , (2 players)
UTG+1 checks, Hero bets $1.50, 1 fold

Total pot: $2.85 | Rake: $0.10

Results:
Hero didn't show 7, 4.
Outcome: Hero won $2.75

Most villains who do this will either c/r their sets on the flop or will choose to c/r the turn. It's better to watch how they play their sets when you aren't in a hand with them, b/c they play their sets the same 90% of the time.