Tighten up UTG.
Tighten up OTB.
I dont know if its just sample size, but think about your 3-bet range OTB.
Probably tighten up in the blinds more.
This is largely guesswork, but I think you're stealing OTB so wide that regs are 3-betting you wide, which is getting you into crappy 4-bet/5-bet bluff spots. A valid adjustment to being 3-bet a bunch is to tighten your button range somewhat. I dont know how much of that is resulting in your red line of doom. Something I've noticed on mine is when the redline heads down, I'm often making speculative calls too much (SCs, Suited Aces, crap like that, to both normal raises and 3-bets).
Spend some time messing around with your HEM report filters and see what pops out at you.
