Update: roll just hit 2200 after a good weekend, so I'll be taking my first stab at 100NL.
When I moved from 25NL to 50NL I erred on the side of "LAG", so this time I think I'll start tighter, and loosen up as I get more comfortable. 25NL-50NL was not that smooth for me, but I've plugged many holes since then so here's hopin' that 100NL will treat me better.