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Here's a chart to give some of the break-even points for Hero given various ranges for Villain's 4bets, flat calls and folds. I've tried to find combinations of parameters that get us Q's about 1/3, 2/5 and 1/2:

Let's talk about a TAGG-reg opening in MP with 14% of all his hands, say something like 22+, AJ+, ATs, KQ, KJs, 76s+ and A2s - A4s, which is spot on 14% and might be reasonable. What will he continue with? Let's say he 4bets QQ+ and AK, flats AQ, AJs, KQ, and 88 - JJ.
So this villain is 14/3/4.5 (that's PFR/4b/flat). That combination isn't on the chart, but it turns out that Hero needs Q = 45% to make the action profitable. Here is the stove for Hero's Squeeze with an sc and Axs, two common light squeeze choices.
Squeeze w/ 98s equity win tie pots won pots tied
Hand 0: 66.354% 65.98% 00.37% 244044828 1371864.00 { JJ-88, AQs-AJs, KQs, AQo, KQo }
Hand 1: 33.646% 33.27% 00.37% 123069108 1371864.00 { 98s }
Squeeze w/ A4s equity win tie pots won pots tied
Hand 0: 59.634% 58.65% 00.98% 220947144 3699358.00 { JJ-88, AQs-AJs, KQs, AQo, KQo }
Hand 1: 40.366% 39.38% 00.98% 148361020 3699358.00 { A4s }
In position squeezing with Axs, Hero's equity is only 5% less than Q, so he should be well able to eke some profit. Since this is a hand I don't much flatting with, it's a perfect candidate for squeezing. Even though sc's flop good, we can probably make more with it flatting since it's a more deceptive hand postflop. (I have a big maths posts on the flopability of sc's and Axs, which I'll get to some time this week.) What about squeezing with a hand like K9s which I would normally fold.
Squeeze w/ K9s equity win tie pots won pots tied
Hand 0: 64.070% 63.24% 00.83% 229576996 3002414.00 { JJ-88, AQs-AJs, KQs, AQo, KQo }
Hand 1: 35.930% 35.10% 00.83% 127426624 3002414.00 { K9s }
This seems to me to be pretty borderline. I probably still fold. You can play around with various combos you typically squeeze, flat or fold and see how they match up playability-wise vs. the needed 45% Q, but remember it's breakeven equity. I'm looking for hands where I can about 50% of the time so the profits take care of the times the original flat caller bombs and when I misjudge Villain's range. So with a PFR of only 14%, I'm squeezing carefully with higher value "light" combos.
The nice thing is that we often face TAGG-reg villains who open more like 18% or 20% but don't adjust their flat calling range (like me, for example, until this post :P). What if the PFR range is 22+, 65s+, Axs, AT+, KJ and KTs+? And what if this reg doesn't adjust his 4b/flatting ranges? Then Q = 34.3%, and our equity is much better with various mediocre hands. Here are a few:
Squeeze w/ JTs equity win tie pots won pots tied
Hand 0: 60.286% 59.90% 00.38% 217450344 1391784.00 { JJ-88, AQs-AJs, KQs, AQo, KQo }
Hand 1: 39.714% 39.33% 00.38% 142774536 1391784.00 { JTs }
Squeeze w/ A8os equity win tie pots won pots tied
Hand 0: 63.412% 62.32% 01.09% 665873892 11673474.00 { JJ-88, AQs-AJs, KQs, AQo, KQo }
Hand 1: 36.588% 35.50% 01.09% 379256856 11673474.00 { A8o }
So you can see the results, and come to your own conclusions. But I've learned a lot. The next step for me is take this and flip toward Hero getting squeezed, reset the EV equation, recalculate Q and then look at continuation ranges Hero can use to adjust in high squeeze games.
Finally, oop sucks. I think people squeeze too light a lot of time oop. Generally, unless we expect Villain's PFR near 20% and continuation range around 8% or 9%, we're going to be hard pressed to show a profit with sc's and Axs generally speaking. But this analysis shows why squeezing is so profitable. There are lots of players who continue with a good bit LESS than 7% of their hands when squeezed, so some nit who's only gonna continue with 5% is just begging for a squeeze any time PFR ~ 11 or 12 if squeezer has position, and any time PFR ~ 13 or 14 if squeezer is oop.
First glance at adjusting. I tried the stove with AA and AKs included in Villain's flat call range (since I tend to mix up my plans with the premium comobs). By the way, this shifts Hero's Q number. Villain is now 14/2.2/5.3, and Hero's Q ~ 33%. The equity number for Axs only decreases by 2%. So shifting premium hands out of the 4b range into the flat call range WITHOUT shifting some less powerful hands back into the 4b range is HORRIBLE. In squeeze happy games, Hero can probably jam with at least 75% of premium combos, just keeping enough the flat range to mix it up slightly. The reason Hero should jam against most squeezes is that to combat the squeeze, 4b'ing is better than flatting. Since Hero needs an uncomfortably wide 4b range, it's good to leave the big hands in there and probably include some of the top end of the flat calling range I specified, say, JJ/AQ type hands.
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