You must remember that most guys at 100NL and 200NL have been NITS themselves in the past (most probably). They know your strategy and exploit it maximally.

Against these thinking players we need to think a little deeper and try to always be one step ahead.

If you are playing on sites where people use HUD you need to use your own stats to your advantage.

On sites where HUD is unavailable I would be very surprised if a NITTY approach was not profitable.