Simulation is irrelevant because it's indistinguishable from non-simulation. If we are in a simulation of a greater being, earthly problems are like if you have a giant field of corn and one of them rots. In the simulation of your cultivation, you pay no mind to it

Besides, whose to say the Universe isn't a cell in the body of trillions of cells in a world of trillions of other bodies with trillions of universe-cells? Human consciousness merging with cyberspace isn't even a blip, and it would last only as long as the one universe does, and that universe only lasts as long as length is measurable within itself