assuming it didn't start sucking makes it hard.
seinfeld was written better, way better, but simpsons brought us homer.
overall, id hafta say seinfeld because it stood out in most aspects, many of which most shows suck at, but it is tough since homer was ridiculously funny. way funnier than george or kramer alone.
the real question is: curb or seinfeld. because you know they're both larry david.
i say curb
edit: oh and 25