The main adjustments are to just go really nuts with stealing in small pots from the Button and Cut Off. The main tip Id give though is to figure out what kind of nits youre playing against and figure out how they react to steals, then figure out the common sense way to exploit it.

A couple of examples of pretty common nitty responses are:

Do they fold a tonne and never adjust? - Steal almost any 2 from the button and still steal a tonne from the CO. If you can get away with it, drop your PFR size down to 2.5bb or even 2bb to give yourself the best odds.

Do they adjust by calling a lot preflop and still folding a lot when they miss? Keep stealing a tonne, and keep your raise size relatively large. Youre building a pot that you will take with a cbet or turn barrel a lot.

Probably the most important thing to remember is that you are beating these guys by figuring out what pots you can get away with stealing when you both miss, and by staying out of the way when he finally gets his AA. Just because you would be looking to play back at you doesnt mean the 10/8 is. Its really easy to go losing a big pot with TPGK or bottom 2 pair when they finally get a hand.

Also, you should still be trying to play this game in a lot of your "good" games. Some of the best games have nits in the blinds to your button, and a few fish in the CO/MP/ whatever. When the fish limp you isoraise and profit, when the fish fold you blindsteal and profit.