I expect him to fold 1pr hands easily here 100% of the time. I expect him to call with any 2pr+. So his calling range is 22/44/JJ/KJo/KJs (KK is out b/c of his stats)

Here is what I take this line with:

AA/KK/AK/22/44/JJ/12+out draws

Let's see how his calling range looks against my range:
20,196 games 0.005 secs 4,039,200 games/sec

Board: 2s Jd 4d Kh
Dead:

equity win tie pots won pots tied
Hand 0: 31.462% 31.46% 00.00% 6354 0.00 { KK+, JJ, 44, 22, AKs, AdQd, AKo }
Hand 1: 68.538% 68.54% 00.00% 13842 0.00 { JJ, 44, 22, KJs, KJo }

So his calling range is more than a 2:1 favorite against my range here (non-discounted). What does that really mean though?

At the time I felt he had to fold 50% of the time to make it profitable, now I am not so sure.