No stats/reads on any of the villains, this was my first hand at the table. I did follow the game a couple of hands before I sat in and UTG shortstack looked like he was there to gamble (he played 1/3 of all pots).

Seat 2: UTG ($212.60 in chips)
Seat 4: CUTOFF ($2483.35 in chips)
Seat 6: BUTTON ($3355.25 in chips)
Seat 7: SB ($3060.60 in chips)
Seat 10: HERO [ AD,QD ] ($2000 in chips)

ANTES/BLINDS
SB posts blind ($10), HERO posts blind ($20).

PRE-FLOP
UTG bets $70, CUTOFF folds, BUTTON folds, SB bets $210, HERO... ?

Should I just call or re-isolate with AQs. I'm certainly ahead of the isolators range.

The isolator clearly looks weak, but he knows that I know that, and because of that also my re-isolation play will look much weaker than a normal 4-bet would (which it is).

I actually did re-isolate and raise to 650 (isolator folded, utg called with 44 and I hit my queen on the turn), but afterwards I started to think that because I had position on the isolator, perhaps just calling would have been a better play? Why give free equity to the shortstack by re-isolating?

Looks a bit like a high-risk, low-reward kind of play...