That is how deep stacks get de-stacked. Don't raise a deep stack all in on the river without the nuts at 200NL unless you're on some kind of bluff. Nobody is gonna call without em. Its kind of like this hand that I played like a fucktard yesterday:

Total number of players : 2
Seat 2: villain ( $941.55 )
Seat 3: hero ( $633.50 )
villain posts small blind [$2].
hero posts big blind [$4].
** Dealing down cards **
Dealt to hero [ Ts Td ]
villain raises [$13].
hero raises [$41].
villain raises [$65].
hero calls [$35].
** Dealing Flop ** [ 8c, 2h, Tc ]
villain checks.
hero checks.
** Dealing Turn ** [ Ad ]
villain checks.
hero bets [$100].
villain raises [$200].
hero calls [$100].
** Dealing River ** [ 3d ]
villain bets [$225].
hero is all-In.
villain calls [$128.50].
villain shows [ Ah, As ] three of a kind, aces.
hero doesn't show [ Ts, Td ] three of a kind, tens.