I've checked out pokerroom's new 5/10, 10/20 and 25/50. 25/50 scared the living shit out of me, some people sitting with deeeeeep stacks ($25k+ at a $5k buyin) Not yet had the balls or anything approaching an absolute bare minimum roll to sit at 50/100. (and probably shouldn't have sat at 25/50 for that matter, but curiosity made the cat just over $2k in 4 hours).
Just to clarify, meant NL