I'm usually only stacking off if the equity I have vs their 4bet range + the dead money in the pot make it +ev to do so.
(HM manager has some good graphs/tables for determining these frequencies)

If they are raising 10% of their hands utg but only 4betting QQ+AK+ (2.5%) then I will probably fold to the 4bet.
(But the 3bet is still profitable because 3/4 times I win their raise + blinds (+-5bb) and 1 x I lose my 3bet (-12bb))

Now you can argue that the 3bet is pretty much a bluff if you are folding to a 4bet in this case, but for me it's very important to have a strong (mainly) linear 3bet range because players will attempt to play back at your 3bets by 4 betting more (sometimes for value and sometimes as a bluff)

And this is actually an effective & very profitable counter strategy to players who have too many weak hands sc's, low pp & air in their 3bet range. (You'll find players like this have a high fold to 4bet%.)

But because I am 3betting a mostly linear range when villian starts to 4bet lighter I am going to have the hands in my range to take advantage of that. In this case if he 4bets more than 3.5% of hands I have the equity to stack off with JJ.

But if you are only 3betting QQ+,AKs & 'some bluffs' vs this utg raiser if he 4bets any more than the avg then he will be the one exploiting you & then you have to either 3bet a tighter range or adjust your 3bets to include a more linear range that has stack off equity vs his wider 4bet range.

I choose normally to 3bet a more linear range than most from the outset (I do add some weaker hands though) so I am as close to being unexploitable pre-flop as possible.

(Note-I'm also aware of the potentially negative post flop implications of this strategy but the adv of getting more money in the pot when I'm ahead of their range pre-flop and having the iniative counter alot of these.)