Well, I'm sure you know this about me already but I prefer the 100NL over 25NL. I've only played 50NL a few times and it seemed like 25 with tighter people. To me, the 100NL players are more predictable, they won't chase and you can protect your hand better. Also, tricky plays seem to work more at the 100 than at the 25. The only thing is that 100NL has more rocks so you have to actually play the player instead of the cards.