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Depends on how comfortable with your post-flop play and your read on your opponent. If they're limping 50%+ and never raising I'm raising to 4BB with Q2+, any suited connectors or double gappers, and basically any 2 suited cards that could make a straight (ex. Q8s).
I try to do this several times early. The effect on their game is two-fold. They tighten up their hand selection and fold more of their buttons, and after they play back at me 2 or 3 times I tighten up my hand selection. Against weaker players 88+ and AQ+ are monster hands once they see you're repopping and folding if they 3 bet.
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