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There are many factors. Stack size, blind size, number of players, etc.
Speaking in generalities here: Typically I won't loosen up much until it's down to 3 players or if I am short stacked. I start out extremely tight, slightly passive. When the blinds progress and players start dropping, I will increase aggression somewhat and move into TAggy territory. When it gets down to 4-5 players is where I'm the most extreme TAggy. When it gets down to 3 players I'll loosen way up and play a solid loose aggressive game, raising most pots preflop and attacking weakness regardless of my hole cards.
Speaking about some specific situations:
If I manage to double up early on from a dumb ass, I will have a little more chip leverage and be willing to play a little more aggressively post flop even if the blinds are still really low and there are a lot of players. So I will move into aggressive territory more quickly if the "my chips pponent chips" ratio is high regardless of blinds.
If it is one of those games where 4 or 5 players drop out in the first couple of blind levels (halelujia), I might consider waiting even longer before loosening up in order to make it ITM. A lot of people will get crazy loose aggressive when it gets short handed, even if the blinds are still low. This is easy to take advantage of if you stick to tight aggression and build a solid table image with the 5 or 6 remaining players.
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