I think you're train of thought has to go beyond what you think HE has - like ender mentioned what are you trying to represent here. If you're gonna take a shot at Hand1 - I'd suggest floating the river and betting or c/r the turn, I don't think anyone would 3bet a set on a board like that.

Hand2 is played weird, If I'm villain here I probably have you on JJ/QQ question is what reads to you have on villain here. If I'm in his spot holding QQ-KK-AA-AK I'm shoving this.

~ Jay G