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Hypothetically, and assuming 100xBB stacks, if you were to call a late position 4xBB open from the BTN with a small pair, you would be getting 25:1 IO. Those are great odds except against the loosest and best postflop players, and therefore a call would almost never be a -EV play (3betting would probably be more +EV, but my point still stands). Though most players are opening a wider range from late positions, 25:1 odds on their stack is still way too good to pass up.
I am going to assume EZDuzit's 3bets ~8-10% of his total hands preflop. If he has a 22-28% PFR in later positions, then he is 3betting ~1/3 of his opening range from those positions - which is reasonable.
For villain in the posted hand, he is being offered 15:1 on EzDuzit's 3bet range, which in absolute terms is fairly small. And EzDuzit will stack off on the flop sometimes (like when he is actually holding Q-Q+, or has A-K and hits TPTK, or if he flops some other second best hand to a set). Calling EzDuzit's 3bet with the IO's villain is being offered would not be a mistake, and in fact is probably the optimal play in that spot.
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