(I realize there are so many what if's and opponent dependent responses but if you can try and ignore those for the moment.)
I'm not sure it is possible to ignore these factors and give any meaningful advice. I don't even fully know whether this is heads-up, or against an opponent whom you want to get heads-up in a larger game.

Either way, how he plays post-flop would have an influence on how I played pre-flop.


EDIT: not just a small influence, given the stark choices of A or B for preflop play - it would depenend entirely on how villain plays post-flop.