I converted my database over to PostgreSQL as soon as I started playing a lot of poker. From the way I understand it, it makes accessing a large database much quicker. I can say that sense I have switched to it load times are much faster than what they use to be.
I also work at a dealership and we have a gigantic database of customers inside of a piece of software we use, and its a SQL database, our IT guy says it the only way to go when you have massive amounts of data.