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Hey mate,
this is a classic application for confidence intervals:
http://en.wikipedia.org/wiki/Confidence_Interval (FYI)
This is pure math/statistics though. Unfortunately they didn't link the source (the original post in the 2+2 forums) and I didn't have time to search for it yet.
If I get the chance I can break down the math. You'll never reach 100% btw, the value will asymptotical approach (?) towards 100% (hope that's the right term in english, I'm German, so I'm kind of at a loss of words here). Ok, let me rephrase that. With an infinite sample size, you would of course be 100% certain of your "true" ROI. I think that's easier to understand 
If you want to have a visual impression:
- take a piece of paper
- draw two axes, x - no of games, y - ROI%
- put in the 4 coordinates you have
- draw a curve matching the 4 coordinates (use a curve template)
Anyways, perhaps the link helps a bit to understand. 
cheers,
elitemob
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