Short answer is yes. Adjusting your open raise sizes to match different goals is appropriate.

In late positions, you have fewer to act behind, so you open a wider range. By opening a wider range, you are more likely to have a lower valued hand post-flop. You get to act IP, so you are more able to play a drawing hand (like suited connectors) correctly. Since there are more drawing hands in your opening range, you want to see more streets than just the flop to realize your drawing value. Starting with a smaller pot going to the flop makes that a bit more affordable.

When in EP, you're opening a tight range, which you can comfortably open for a couple BB more than LP. Your range is tighter, so you're more confident that you'll win, and there are more people to act behind, so you want to thin it down to heads-up with those hands.

The tendencies of the blinds are important, too. It's highly likely that neither blind will be playing a wide enough range to stop your blind steals. If you can steal the blinds from the BTN with a min-raise, and at least one of the blinds aren't calling you almost every time, then you are already winning money. You can literally fold any hand post flop and you'll still be profitable from the BTN. You're getting 1.5 BB profit for an investment of 2 BB.

W*1.5 - L*2 = 0
W*1.5 = L*2
1.5/2 = L/W
L/W = 0.75

This illustrates that either or both of the blinds need to call or raise your BTN min raise 75% of the time in order for your blind steal to lose profitability PRE. That means that if the blinds are not defending at least that often, then you are printing monies by simply betting to steal and ALWAYS FOLDING w/o any bets post flop. Basically, if every hand in your range PRE was a bluff, you'd still be making money off the blinds.

This is an extreme example, but you can see the mathematical result. Betting less to steal blinds makes your life post-flop much easier.