Yes and no.....the overall strategy is basically the same, however in a two-table SnG you must be able to change gears from tight to loose...back to tight again. Two-tables are unique because you start out playing a full table, then eventually have to play short handed....then back to a full table again...then short handed with significant sized stacks and generally higher blinds (2-tables take longer)
The potential ROI is higher for the same investment, and they give you a lot of practice in many aspects of the game....Changing gears, short stack play, large stack play, short handed play, and hopefully heads up play. They are really a good starting point for someone who wants to become a MTT player, although MTTs have thier own unique set of challenges...two table SnGs are a good starting point.