Maybe your idea of tricking nature and her idea of defying nature are more aligned than you think (but I don't really know because I'm not entirely sure what you mean by that).

She's kind of an androgynous, aggressive loudmouth who is not stereotypically feminine in many ways, liked to crossdress when she was younger, wanted to be Napoleon, etc etc. I think this is what she means by defying.. Which isn't to say you act in defiance for the sake of it, but rather that you actualize yourself as an individual rather than slavishly doing what you're told to do because of your gender or whatever else.

I don't think she means something like.. let's see.. a 115 lb girl trying to become a UFC champ in the men's divisions, lol.